There are multiple factors
influencing immunity, including but not limited to, medical history,
vaccine type, method of administration, age, and species being
vaccinated.
( Pirbright Institute )
Vaccines
are a vital part of keeping all livestock healthy. Vaccines help in the
prevention of disease, which results in less utilization of antibiotics
due to fewer sick animals. Vaccines provide protective immunity
approximately 21 days following the initial vaccination in the majority
of livestock. Some vaccines may require a booster vaccination(s) to
ensure immunity for the period designated by the manufacturer. There are
multiple factors influencing immunity, including but not limited to,
medical history, vaccine type, method of administration, age, and
species being vaccinated. A valid Vet-Client-Patient relationship will
help you as you select the vaccine of choice for your livestock health
program.
Vaccine Types
You are probably utilizing one of two types of vaccines: inactivated
(“killed”) vaccines, which contain bacteria or viruses that have been
inactivated by heat or chemicals, or modified-live virus (MLV) vaccines,
which contain whole viruses that have been altered in such a way that,
while they are able to multiply within the body, their ability to cause
disease has been taken away.
So how do vaccines become worthless? Proteins are the major
components of the organisms that make up both killed and MLV vaccines.
Proteins are denatured by the interaction of two major factors: time and
temperature. In addition, most common disinfectants will render
modified live organisms inactive. So the anti-bacterial soap or even
city or rural water, which contains chlorine, can have an effect on
vaccines, when residues are present in your syringes or transfer
needles. Thus, rinse with distilled water which is near the boiling
point.
Things to Consider
Other considerations for handling, storing and using vaccines are as follows:
PURCHASING AND USE CONSIDERATIONS OF VACCINES
Check expiration dates and make sure you can use it before it
expires. For MLV vaccines purchase smaller dose instead of larger dose
vials, which will enable using the vaccine in a shorter time period.
Also remember to purchase an adequate number of needles and plan on
replacing the needle about every 5-10 head of cattle. Do not straighten a
bent needle, replace it!
TRANSPORTING AND STORING VACCINES
Check the recommended storage temperature, and use a cooler while
transporting and while vaccinating to keep the vaccine at the
recommended temperature and also to minimize exposure to sunlight.
Typically this temperature is between 35 degrees to 45 degrees F unless
the product label advises otherwise. Check your refrigerator’s
temperature periodically to assure that it is working properly and is
keeping the vaccines at the correct temperature.
EQUIPMENT AND WORK AREA
Make sure your equipment is clean and rinsed with distilled water to
remove any residues. Set up an area for syringes such that they are kept
cool, shaded, and dust-free while working.
WHILE WORKING
Keep vaccines in a cooler with ice packs in summer or possibly hot
packs in winter if it is too cold. (Check vaccine labels for proper
storage temperature.) Don’t mix more MLV vaccine than can be used in 30
minutes. If using MLV vaccines, only rehydrate the vials either one at a
time or as they are needed. Make sure you are using a clean transfer
needle and use only the diluent supplied by the manufacturer to
rehydrate the vaccine. Always use a brand-new needle to draw up the
vaccine into the syringe. When using needle-free injection systems, or
syringes that draw doses from a tube attached to the vaccine bottle,
care should be taken to assure the bottle and tubing stay cool and
shaded from sunlight.
NO JOB IS DONE ‘TIL THE CLEAN-UP
Discard any mixed MLV vaccines that are not used, as they are only
viable for about an hour or two after reconstitution. Discard any
partial bottles of inactivated vaccine that have been contaminated by
dirty needles. Return unmixed MLV and unused inactivated vaccines to
proper storage as soon as possible. Clean syringes, transfer needles,
and tubing. Make sure to rinse with distilled, boiling water inside and
out. Follow the manufacturer’s directions on proper cleaning and
maintenance of needle-free injection systems. Burn empty vaccine bottles
or follow label directions for disposal of containers and needles.
The Bottom Line
The success of any livestock vaccination program depends on the
effectiveness of the vaccine used. Vaccines-which in essence are
suspensions of biological organisms – will become ineffective if proper
storage and handling recommendations are not followed. Thus, if they are
not followed you have in essence wasted a lot of money and time and
have increased the potential for livestock illness and death loss due to
disease that might have been avoided.
Sources:
Daly, R., Price, A. (March, 2010). Livestock Vaccines: How They Work
and How to Ensure They Do Their Job. ExEx11025. SDSU Extension Extra.
Brookings, SD.
Williams, P. D., & Paixão, G. (2018). On-farm storage of livestock
vaccines may be a risk to vaccine efficacy: a study of the performance
of on-farm refrigerators to maintain the correct storage temperature.
BMC veterinary research, 14(1), 136. doi:10.1186/s12917-018-1450-z